Boriosi JP, Eickhoff JC, Hollman GA. Safety and Efficacy of Buccal Dexmedetomidine for MRI Sedation in School-Aged Children. Hosp Pediatr. 2019 May;9(5):348-354.

In a selected population of pediatric patients, buccal dexmedetomidine with or without oral midazolam provides adequate sedation for most MRI studies with few adverse effects, but given a failure rate of almost 20%, modifications to buccal dexmedetomidine dosing should be investigated. Further studies are required to identify optimal buccal dexmedetomidine dose and which patients are ideal for buccal dexmedetomidine sedation for MRI.