Safe Selection: A Multi-Center Analysis of Exclusion Criteria in Pediatric Ambulatory Surgery Centers

Chernishof V, Nour S, Chen SE, Na YB, Prichett L, Vanderhoek SM. Safe Selection: A Multi-Center Analysis of Exclusion Criteria in Pediatric Ambulatory Surgery Centers. Paediatr Anaesth. 2025 Nov;35(11):962-968. doi: 10.1111/pan.70037. Epub 2025 Aug 14. PMID: 40810702. Full text access for Children’s and Emory users. Abstract Background: In the United States, over a quarter of outpatient…

Articles regarding Fasting / NPO Guidelines and Practice in Pediatric Anesthesia

Cho E, Song J, Huh J, Kang IS, Kim HJ, Youn IY, Lee H, Kwak JH. Evaluation of Modified Fasting Protocols to Shorten Fasting Time Before Sedation in Children: A Prospective Randomized Noninferiority Trial. Paediatr Anaesth. 2025 Sep;35(9):753-760. doi: 10.1111/pan.15142. Epub 2025 Jun 18. PMID: 40530767; PMCID: PMC12340336. Free full text access. Abstract Backgrounds: Guidelines for…

New articles related to Pediatric Sedation Practices, Safety, and Efficacy

Biro Y, Tabi Y, Gileles-Hillel A, Rekhtman D. Evaluating the safety and efficacy of rapid bolus-only dexmedetomidine for pediatric EEG sedation: a retrospective study. Eur J Pediatr. 2025 Nov 18;184(12):772. doi: 10.1007/s00431-025-06567-x. PMID: 41251877; PMCID: PMC12627106. Free full text article. Abstract Dexmedetomidine is an α2-adrenergic receptor agonist known for its sedative and analgesic properties. It…

Non-Invasive Capnography Versus Pulse Oximetry for Early Detection of Respiratory Depression During Pediatric Procedural Sedation: A Prospective Observational Study

Català Altarriba L, Yeh Hsi S, Ravit AM, Brió Sanagustín S, González-Rioja X. Non-Invasive Capnography Versus Pulse Oximetry for Early Detection of Respiratory Depression During Pediatric Procedural Sedation: A Prospective Observational Study. Children (Basel). 2025 Jul 16;12(7):938. doi: 10.3390/children12070938. PMID: 40723131; PMCID: PMC12293103. Free full text access. Abstract Background/objectives: Continuous ventilation monitoring during pediatric sedation is…

Drugs for Procedural Sedation and Analgesia in Children: A Systematic Review and Meta-analysis

Hamdan S, Adelou S, Jungo S, Diakonoff H, Treluyer JM, Fron Chabouis H, Smail-Faugeron V. Drugs for Procedural Sedation and Analgesia in Children: A Systematic Review and Meta-analysis. Drugs R D. 2025 Sep;25(3):179-193. doi: 10.1007/s40268-025-00522-9. Epub 2025 Aug 13. PMID: 40804602; PMCID: PMC12460213. Free full text access. Abstract Background and objectives: Performing medical procedures on children…

New articles on Intranasal Drugs

Tsze DS, Woodward HA, McLaren SH, Leu CS, Venn AMR, Hu NY, Flores-Sanchez PL, Stefan BR, Shen ST, Ekladios MJ, Cravero JP, Dayan PS. Optimal Dose of Intranasal Midazolam for Procedural Sedation in Children: A Randomized Clinical Trial. JAMA Pediatr. 2025 Sep 1;179(9):979-986. doi: 10.1001/jamapediatrics.2025.2181. PMID: 40720114; PMCID: PMC12305440. Full text access for Children’s and…

Error Traps in Pediatric Total Intravenous Anesthesia Knowledge Gaps and a Practical Perspective

Guimarães Ferreira Fonseca L, Keys A, Hart M, Skowno J. Error Traps in Pediatric Total Intravenous Anesthesia Knowledge Gaps and a Practical Perspective. Paediatr Anaesth. 2025 Dec;35(12):996-1015. doi: 10.1111/pan.70051. Epub 2025 Sep 16. PMID: 40955803. Full text Children’s and Emory access. Abstract Pediatric total intravenous anesthesia (TIVA) with propofol is well-established, safe, and offers advantages…

New articles for General Sedation

McPhaden E, Tobias JD, Smith A. Clinical Experience With Remimazolam in Neuroanesthesiology and Neurocritical Care: An Educational Focused Review. J Clin Med Res. 2025 Mar;17(3):125-135. doi: 10.14740/jocmr6193. Epub 2025 Mar 10. PMID: 40115836; PMCID: PMC11922631. Free full text access. Abstract Remimazolam is an ultrashort-acting benzodiazepine, approved for clinical use by the United States Food &…

New articles related to Dentistry

Sun Y, Li Q. Nasopharyngeal airway-assisted sedation enhances oxygenation and reduces perioperative adverse events in pediatric dental surgery: A comparative clinical study. J Investig Med. 2025 May 30:10815589251348914. doi: 10.1177/10815589251348914. Epub ahead of print. PMID: 40444890. Full text access for Children’s and Emory users. Abstract Perioperative airway management during pediatric dental procedures remains challenging, particularly…

New articles relating to MRI

Kim SY, Booth JM, Staffa SJ, Kordun A, Yu J, Cravero JP. A dose-ranging pilot trial of dexmedetomidine-propofol in children undergoing magnetic resonance imaging. J Anesth. 2025 May 11. doi: 10.1007/s00540-025-03511-z. Epub ahead of print. PMID: 40349256. Full text access for Children’s and Emory users. Abstract The optimal sedation/anesthesia technique for magnetic resonance imaging (MRI)…

New articles relating to Ketamine

Udo SI, Rich C, Lyon J. Guideline on the Use of Intravenous Ketamine for Procedural Sedation in the Children’s Emergency Department: A Quality Improvement Project. Cureus. 2024 Dec 4;16(12):e75085. doi: 10.7759/cureus.75085. PMID: 39634206; PMCID: PMC11616467. Free full text access. Abstract In pediatric emergency medicine, sedation is crucial for performing some therapeutic procedures in children. Ketamine…

New articles relating to General Sedation

Bacha T, Kejela S, Hagen SA. Establishing the first ever pediatric procedural sedation clinic in a low-income country: Assessment of the safety and efficacy. BMC Pediatr. 2025 Jan 31;25(1):85. doi: 10.1186/s12887-024-05351-4. PMID: 39891070; PMCID: PMC11783765. Free full text access. Abstract Background: Pediatric sedation clinics are rare in low-income countries. Our aim is to describe the establishment…

New articles relating to Dexmedetomidine

Jin QQ, Cai WC, Zhou YF, Zhang YT, Chen G, Xu MT, Li J, Yuan KM. Comparison of a ready-to-use intranasal dexmedetomidine spray with traditional intranasal dexmedetomidine drops for sedation in preschool children: a prospective, randomized, controlled study. Front Pharmacol. 2025 Jan 23;16:1528612. doi: 10.3389/fphar.2025.1528612. PMID: 39917619; PMCID: PMC11799867. Free full text access. AbstractPurpose: This study…

New articles relating to Dexmedetomidine

Li Y, Jiang Y, Zhang L. The effect of different dosage of intranasal dexmedetomidine on preventing emergence delirium or agitation in children: A network meta-analysis of randomized controlled trials. PLoS One. 2024 Sep 6;19(9):e0304796. doi: 10.1371/journal.pone.0304796. PMID: 39240955; PMCID: PMC11379244. Free full text access. Abstract Background: The clinical evidence for the effects of different doses of…

New articles relating to Ketamine

Wells K, Calleo V. Safety and Depth of Sedation With Ketamine Alone Versus Ketamine With Midazolam in Pediatric Fracture Reduction: A Retrospective Chart Review. Pediatr Emerg Care. 2024 Aug 27. doi: 10.1097/PEC.0000000000003185. Epub ahead of print. PMID: 39190367. Full text access for Children’s and Emory users. Abstract Study objectives: Pediatric patients with extremity fractures often require…

New articles relating to Remimazolam

Pieri M, D’Andria Ursoleo J, Di Prima AL, Bugo S, Barucco G, Licheri M, Losiggio R, Frau G, Monaco F; Collaborators. Remimazolam for anesthesia and sedation in pediatric patients: a scoping review. J Anesth. 2024 Oct;38(5):692-710. doi: 10.1007/s00540-024-03358-w. Epub 2024 Jun 7. PMID: 38844707. Full text access for Children’s and Emory users. Anesthetic management of…

New articles relating to Midazolam

Jampana S, Harrison LC, McCall J, Ferrante RR, Winer JC, Kink RJ, Rogers NG. Evaluation of Intranasal Fentanyl and Midazolam Among Inpatient Pediatric Patients. Hosp Pediatr. 2024 Oct 1;14(10):e439-e442. doi: 10.1542/hpeds.2024-007819. PMID: 39301611. Full text access for Children’s and Emory users. AbstractObjectives: The use of intranasal (IN) analgesics and sedatives has been studied among pediatrics patients…

New articles relating to Oxygenation

Green SM, Bhatt M, Roback MG. Supplemental Oxygen for Pediatric Procedural Sedation: Common Sense Precaution or False Reassurance? Ann Emerg Med. 2024 Jun 21:S0196-0644(24)00293-2. doi: 10.1016/j.annemergmed.2024.05.025. Epub ahead of print. PMID: 38912997. Full text access for Children’s and Emory users. Editorial Should we administer prophylactic supplemental oxygen for procedural sedation? Many clinicians and settings do…

New articles relating to General Sedation

Tom D, Reeves S. Pediatric Procedural Sedation. Pediatr Ann. 2024 Sep;53(9):e324-e329. doi: 10.3928/19382359-20240703-06. Epub 2024 Sep 1. PMID: 39240178. Full text access for Children’s and Emory users. AbstractPediatric procedural sedation (PPS), formerly known as conscious sedation, is often used outside the operating room for various procedures. Twenty years ago, nearly all cases of PPS were…

Safe pediatric procedural sedation and analgesia by anesthesiologists for elective procedures: A clinical practice statement from the European Society for Paediatric Anaesthesiology

Zielinska M, Bartkowska-Sniatkowska A, Becke K, Höhne C, Najafi N, Schaffrath E, Simic D, Vittinghoff M, Veyckemans F, Morton N. Safe pediatric procedural sedation and analgesia by anesthesiologists for elective procedures: A clinical practice statement from the European Society for Paediatric Anaesthesiology. Paediatr Anaesth. 2019 Jun;29(6):583-590. doi: 10.1111/pan.13615. Epub 2019 Mar 13. PMID: 30793427. Full…

Effective and safe pediatric sedation

Jang YE, Kim JT. Effective and safe pediatric sedation. Anesth Pain Med (Seoul). 2024 Jul 23. doi: 10.17085/apm.24046. Epub ahead of print. PMID: 39069650. Full text access for Children’s and Emory users. Abstract Pediatric sedation is a crucial tool for minimizing pain and anxiety during procedures and examinations in children. However, it is not without…

Natural airway as an alternative to intubation for pediatric endoscopic esophageal foreign body removal: A retrospective cohort study of 326 patients

Lonsdale H, Rodriguez K, Shargo R, Ekblad M, Brown JM, Dolan I, Fierstein JL, Miller A, Dey A, Peck J, Rehman MA, Wilsey MJ. Natural airway as an alternative to intubation for pediatric endoscopic esophageal foreign body removal: A retrospective cohort study of 326 patients. Paediatr Anaesth. 2024 Apr 9. doi: 10.1111/pan.14888. Epub ahead of…

A randomized, double-blind, dose-controlled study of the use of dexmedetomidine alone for procedural sedation of children and adolescents undergoing MRI scans

Khan U, Hammer GB, Duncan-Azadi C, Suzuki Y, Chiles D, Chime S, Chappell P. A randomized, double-blind, dose-controlled study of the use of dexmedetomidine alone for procedural sedation of children and adolescents undergoing MRI scans. Paediatr Anaesth. 2024 Feb 16. doi: 10.1111/pan.14857. Epub ahead of print. PMID: 38363011. Full text access for Children’s and Emory…

Comparison of gastric emptying time between breast-fed and formula milk-fed infants less than 6 months old, using gastric ultrasound-An observational study.

Das D, Trikha A, Kaur M, Muthiah T, Pandey RK, Ankalji B, Madhusudhan KS, Srivastava DN, Singh PM. Comparison of gastric emptying time between breast-fed and formula milk-fed infants less than 6 months old, using gastric ultrasound-An observational study. Paediatr Anaesth. 2024 Feb 7. doi: 10.1111/pan.14841. Epub ahead of print. PMID: 38323713. Full text access for…

Efficacy and Safety of Ketamine-Dexmedetomidine Versus Ketamine-Propofol Combination for Periprocedural Sedation: A Systematic Review and Meta-analysis.

Elsaeidy AS, Ahmad AHM, Kohaf NA, Aboutaleb A, Kumar D, Elsaeidy KS, Mohamed OS, Kaye AD, Shehata IM. Efficacy and Safety of Ketamine-Dexmedetomidine Versus Ketamine-Propofol Combination for Periprocedural Sedation: A Systematic Review and Meta-analysis. Curr Pain Headache Rep. 2024 Jan 12. doi: 10.1007/s11916-023-01208-0. Epub ahead of print. PMID: 38214834. Full text access for Children’s and…

Intranasal Dexmedetomidine Use in Pediatric Patients for Anxiolysis in the Emergency Department

Kenneally A, Cummins M, Bailey A, Yackey K, Jones L, Carter C, Dugan A, Baum RA. Intranasal Dexmedetomidine Use in Pediatric Patients for Anxiolysis in the Emergency Department. Pediatr Emerg Care. 2023 Sep 1;39(9):685-691. doi: 10.1097/PEC.0000000000002901. Epub 2023 Jan 5. PMID: 36728557. Full text access for Children’s and Emory users. Abstract Objectives: In recent years, dexmedetomidine…

Multiple General Anesthesia in Children: A Systematic Review of Its Effect on Neurodevelopment

Colletti G, Di Bartolomeo M, Negrello S, Geronemus RG, Cohen B, Chiarini L, Anesi A, Feminò R, Mariotti I, Levitin GM, Rozell-Shannon L, Nocini R. Multiple General Anesthesia in Children: A Systematic Review of Its Effect on Neurodevelopment. J Pers Med. 2023 May 21;13(5):867. doi: 10.3390/jpm13050867. PMID: 37241037; PMCID: PMC10222791. Free full text access. Abstract…

Controversies in anesthesia-induced developmental neurotoxicity

Useinovic N, Jevtovic-Todorovic V. Controversies in anesthesia-induced developmental neurotoxicity. Best Pract Res Clin Anaesthesiol. 2023 Mar;37(1):28-39. doi: 10.1016/j.bpa.2023.03.004. Epub 2023 Mar 27. PMID: 37295851; PMCID: PMC10258891. Full text access for Children’s and Emory users. Abstract Advances in the field of pediatric anesthesiology have enabled the performance of complex and life-saving procedures with minimal patient discomfort.…

Neuroprotective strategies in anesthesia-induced neurotoxicity

Andropoulos DB. Neuroprotective strategies in anesthesia-induced neurotoxicity. Best Pract Res Clin Anaesthesiol. 2023 Mar;37(1):52-62. doi: 10.1016/j.bpa.2022.11.005. Epub 2022 Dec 5. PMID: 37295854. Full text access for Children’s and Emory users. Abstract Over the past 20 years, hundreds of preclinical studies of the developing central nervous system have been published concluding that the common γ-aminobutryic acid…

Pediatric Sedation

These posts are intended to be educational and not medical advice.